![]() ![]() These drugs are used concurrently with statins for patients who have hypercholesterolemia that is inadequately controlled with statin monotherapy. Summary Second-line lipid-lowering agents include fibrates, bile acid resins, niacin, and cholesterol absorption inhibitors.Unlike other classes of cholesterol-reducing compounds including statins and bile acid sequestrants, ezetimibe has a distinct mechanism of action involving the sterol transporter Niemann-Pick C1-Like 1 (NPC1L1), and is unique in that it does not affect the absorption of fat-soluble nutrients such as fat-soluble vitamins, triglycerides, or bile a. Zetia works to reduce the amount of cholesterol your body absorbs. Zetia is used to treat high cholesterol in people who cannot control their cholesterol levels by diet and exercise alone. ![]()
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